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Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI

Platelets are not only central actors of hemostasis and thrombosis but also of other processes including inflammation, angiogenesis, and tissue regeneration. Accumulating evidence indicates that these "non classical" functions of platelets do not necessarily rely on their well-known abilit...

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Tác giả chính:	Véronique, Ollivier, Varouna, Syvannarath, Angèle, Gros
Ngôn ngữ:	English
Năm xuất bản:	Public Library of Science (PLoS) 2018
Chủ đề:	Medicine Science
Truy cập Trực tuyến:	http://lrc.quangbinhuni.edu.vn:8181/dspace/handle/DHQB_123456789/4053
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spelling	oai:localhost:DHQB_123456789-40532018-10-22T08:45:04Z Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI Véronique, Ollivier Varouna, Syvannarath Angèle, Gros Medicine Science Platelets are not only central actors of hemostasis and thrombosis but also of other processes including inflammation, angiogenesis, and tissue regeneration. Accumulating evidence indicates that these "non classical" functions of platelets do not necessarily rely on their well-known ability to form thrombi upon activation. This suggests the existence of non-thrombotic alternative states of platelets activation. We investigated this possibility through dose-response analysis of thrombin- and collagen-induced changes in platelet phenotype, with regards to morphological and functional markers of platelet activation including shape change, aggregation, P-selectin and phosphatidylserine surface expression, integrin activation, and release of soluble factors. We show that collagen at low dose (0.25 µg/mL) selectively triggers a platelet secretory phenotype characterized by the release of dense- and alpha granule-derived soluble factors without causing any of the other major platelet changes that usually accompany thrombus formation. Using a blocking antibody to glycoprotein VI (GPVI), we further show that this response is mediated by GPVI. Taken together, our results show that platelet activation goes beyond the mechanisms leading to platelet aggregation and also includes alternative platelet phenotypes that might contribute to their thrombus-independent functions. 2018-09-11T01:36:00Z 2018-09-11T01:36:00Z 2014-08 1932-6203 (Online) http://lrc.quangbinhuni.edu.vn:8181/dspace/handle/DHQB_123456789/4053 en Public Library of Science (PLoS)
institution	Trung tâm Học liệu Đại học Quảng Bình (Dspace)
collection	Trung tâm Học liệu Đại học Quảng Bình (Dspace)
language	English
topic	Medicine Science
spellingShingle	Medicine Science Véronique, Ollivier Varouna, Syvannarath Angèle, Gros Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI
description	Platelets are not only central actors of hemostasis and thrombosis but also of other processes including inflammation, angiogenesis, and tissue regeneration. Accumulating evidence indicates that these "non classical" functions of platelets do not necessarily rely on their well-known ability to form thrombi upon activation. This suggests the existence of non-thrombotic alternative states of platelets activation. We investigated this possibility through dose-response analysis of thrombin- and collagen-induced changes in platelet phenotype, with regards to morphological and functional markers of platelet activation including shape change, aggregation, P-selectin and phosphatidylserine surface expression, integrin activation, and release of soluble factors. We show that collagen at low dose (0.25 µg/mL) selectively triggers a platelet secretory phenotype characterized by the release of dense- and alpha granule-derived soluble factors without causing any of the other major platelet changes that usually accompany thrombus formation. Using a blocking antibody to glycoprotein VI (GPVI), we further show that this response is mediated by GPVI. Taken together, our results show that platelet activation goes beyond the mechanisms leading to platelet aggregation and also includes alternative platelet phenotypes that might contribute to their thrombus-independent functions.
author	Véronique, Ollivier Varouna, Syvannarath Angèle, Gros
author_facet	Véronique, Ollivier Varouna, Syvannarath Angèle, Gros
author_sort	Véronique, Ollivier
title	Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI
title_short	Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI
title_full	Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI
title_fullStr	Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI
title_full_unstemmed	Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI
title_sort	collagen can selectively trigger a platelet secretory phenotype via glycoprotein vi
publisher	Public Library of Science (PLoS)
publishDate	2018
url	http://lrc.quangbinhuni.edu.vn:8181/dspace/handle/DHQB_123456789/4053
_version_	1717292469912076288
score	9,463379

Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI

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