Please use this identifier to cite or link to this item: http://lrc.quangbinhuni.edu.vn:8181/dspace/handle/DHQB_123456789/3997
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dc.contributor.authorJan T, engler-
dc.contributor.authorIva, Kapustíková-
dc.contributor.authorMatúš, Peško-
dc.date.accessioned2018-09-06T04:02:55Z-
dc.date.available2018-09-06T04:02:55Z-
dc.date.issued2013-
dc.identifier.urihttp://lrc.quangbinhuni.edu.vn:8181/dspace/handle/DHQB_123456789/3997-
dc.description.abstractA series of twenty substituted 2-hydroxy-3-[(2-aryloxyethyl)amino]propyl 4-[(alkoxycarbonyl)amino]benzoates were prepared and characterized. As similar compounds have been described as potential antimycobacterials, primary in vitro screening of the synthesized carbamates was also performed against two mycobacterial species. 2-Hydroxy-3-[2-(2,6-dimethoxyphenoxy)ethylamino]-propyl 4-(butoxycarbonylamino)benzoate hydrochloride, 2-hydroxy-3-[2-(4-methoxyphenoxy)ethylamino]-propyl 4-(butoxycarbonylamino)benzoate hydrochloride, and 2-hydroxy-3-[2-(2-methoxyphenoxy)ethylamino]-propyl 4-(butoxycarbonylamino)benzoate hydrochloride showed higher activity against M. avium subsp. paratuberculosis and M. intracellulare than the standards ciprofloxacin, isoniazid, or pyrazinamide. Cytotoxicity assay of effective compounds was performed using the human monocytic leukaemia THP-1 cell line. Compounds with predicted amphiphilic properties were also tested for their effects on the rate of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. All butyl derivatives significantly stimulated the rate of PET, indicating that the compounds can induce conformational changes in thylakoid membranes resulting in an increase of their permeability and so causing uncoupling of phosphorylation from electron transport.en_US
dc.language.isoenen_US
dc.publisherHindawi Limiteden_US
dc.subjectScience:en_US
dc.subjectScienceen_US
dc.titleSynthesis and Biological Evaluation of 2-Hydroxy-3-[(2-aryloxyethyl)amino]propyl 4-[(Alkoxycarbonyl)amino]benzoatesen_US
Appears in Collections:Human ecology. Anthropogeography

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